PRODUCTS
We combine peptide science, manufacturing capability and cosmetic application expertise to help customers create innovative beauty products.
Expression-Line Peptide
CollaCyclo™
INCI
CYCLO Hexapeptide-133
Applications
Facial Care · Barrier Care
Certifications & IP
Available Formats
Powder
Solution
Formulation-ready liquid
Key Benefits
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Integrin Signaling Support
Barrier Protein & Lipid Support
Barrier Strength & HydrationMechanism of Action
Cosdermo® CollaCyclo uses a cyclic peptide architecture to interact with integrins on keratinocytes and regulate intercellular signaling. This supports the synthesis and organization of key barrier proteins and lipids, including filaggrin, loricrin and ceramides, helping reinforce barrier integrity and reduce transepidermal water loss.
Efficacy Data
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In Vivo:Helps reduce the appearance of wrinkles and TEWL while improving skin elasticity and hydration after 28 days. |
In Vitro:Supports type I collagen, fibronectin, elastin, hyaluronic acid and type IV collagen-related activity in the tested models. |
Technical Information | 500 ppm Solution
| Parameter | Information |
| INCI Name | CYCLO Hexapeptide-133 |
| Product Form | Colorless to pale yellow clear liquid |
| Nominal Concentration | 500 ppm |
| Storage | Store in a dry, dark place at 2–8°C. |
| Transportation | Can be transported at room temperature. |
| Availability | Detailed technical information is available upon request. |
Formulation Guide
Recommended Use Level
1–10%
Detailed Formulation Guidance
Available upon request.
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