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Expression-Line Peptide

Cosdermo™ INST-500 Amplified™

A concentrated cosmetic peptide solution featuring Acetyl Hexapeptide-8, designed to modulate neuromuscular signaling and support both immediate and long-lasting improvement in the appearance of dynamic expression lines.

INCI

Acetyl Hexapeptide-8

Applications

Facial Care · Eye Care

Certifications & IP

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Available Formats

Powder

Whitederpurity
Whiteder

Solution

500 ppm
Colorless formulation-ready liquid

Key Benefits

Expression-Line Smoothing

Helps visibly soften dynamic expression lines associated with repetitive facial movement.

Neuromuscular Signaling

Supports modulation of SNARE complex formation and acetylcholine-related signaling.

Immediate & Long-Lasting Care

Demonstrates rapid wrinkle-smoothing activity together with continued improvement over extended use.

Mechanism of Action

Cosdermo® INST-500 Amplified features Acetyl Hexapeptide-8, a cosmetic peptide structurally related to SNAP-25. By competing in the SNARE complex formation process, it helps reduce acetylcholine release and the neuromuscular signaling associated with repetitive facial contraction. This activity supports a smoother appearance of dynamic expression lines.

Efficacy Data

In Vivo:

Immediate & Long-Lasting Wrinkle Smoothing Demonstrates rapid improvement in under-eye fine lines and crow’s feet, with visible effects from 30 minutes and continued improvement through 28 days.

In Vitro:

Helps reduce muscle contraction by inhibiting acetylcholine and glutamate release.

Powder Solution

Technical Information | 500 ppm Solution

Parameter	Information
INCI Name	Acetyl Hexapeptide-8
Product Form	Colorless clear liquid
Nominal Concentration	500 ppm
Solubility	Water-soluble
Storage	Store in a dry, dark place at 2–8°C for long-term storage.
Transportation	Can be transported at room temperature.
Availability	Detailed technical information is available upon request.

Formulation Guide

Recommended Use Level

1–8%

Detailed Formulation Guidance

Available upon request.

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